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中华结直肠疾病电子杂志 ›› 2016, Vol. 05 ›› Issue (06) : 458 -462. doi: 10.3877/cma.j.issn.2095-3224.2016.06.001

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肿瘤退缩分级标准的对比及其在直肠癌诊治中的应用进展
谭伊诺1, 陈海燕1, 丁克峰1,()   
  1. 1. 310009 杭州,浙江大学医学院附属第二医院肿瘤外科
  • 收稿日期:2016-07-19 出版日期:2016-12-25
  • 通信作者: 丁克峰
  • 基金资助:
    2014年中国国家卫生行业公益性基金项目(No.201402015); 国家自然科学基金项目(No.81272455,81472664); 浙江省重点研发项目(No.2016CG1360721)

Criteria of tumor regression grade and its application in diagnosis and treatment of rectal cancer

Yinuo Tan1, Haiyan Chen1, Kefeng Ding1,()   

  1. 1. Department of Surgical Oncology, The Second Affiliated Hospital of Zhejiang Medical University, Hangzhou 310009, China
  • Received:2016-07-19 Published:2016-12-25
  • Corresponding author: Kefeng Ding
  • About author:
    Corresponding author: Ding Kefeng, Email:
引用本文:

谭伊诺, 陈海燕, 丁克峰. 肿瘤退缩分级标准的对比及其在直肠癌诊治中的应用进展[J/OL]. 中华结直肠疾病电子杂志, 2016, 05(06): 458-462.

Yinuo Tan, Haiyan Chen, Kefeng Ding. Criteria of tumor regression grade and its application in diagnosis and treatment of rectal cancer[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2016, 05(06): 458-462.

随着新辅助治疗在直肠癌中的规范化推广,肿瘤退缩分级(TRG)标准逐渐引起广泛关注和重视。多项研究证实TRG与直肠癌患者新辅助治疗反应、生存预后有一定相关性,在患者生存预测、随访和临床诊疗策略等方面均有应用前景,甚至也有报道考虑将其纳入临床试验替代终点。但是目前TRG标准各异,尚未统一化、规范化,故本文旨在对目前常见TRG标准进行汇总对比,并进一步探讨其在直肠癌诊治中的临床应用。

Along with the neoajuvant treatment popularized in rectal cancer treatment, tumor regression grade (TRG) has gradually attracted broad attention. Several studies have validated that TRG correlated well with neoajuvant treatment response and prognosis of patients, thus TRG has broad application prospect in prognosis prediction, follow-up and clinical decision, some other researches began to consider it as a surrogate endpoint in clinical trials. However, different systems of TRG couldn′t be unified and standardized. This review was to make a comparison of several popular systems of TRG and explore the clinical application of TRG in rectal cancer treatment.

表1 目前多种TRG分级的汇总对比
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