切换至 "中华医学电子期刊资源库"

中华结直肠疾病电子杂志 ›› 2015, Vol. 04 ›› Issue (04) : 385 -391. doi: 10.3877/cma.j.issn.2095-3224.2015.04.08

所属专题: 文献

专家论坛

胃肠胰神经内分泌肿瘤的临床诊治
朱利明1,(), 钟海均1   
  1. 1. 310022 杭州,浙江省肿瘤医院胃肠肿瘤内科
  • 收稿日期:2015-05-12 出版日期:2015-08-25
  • 通信作者: 朱利明

Clinical diagnosis and treatment of gastrointestinal pancreatic neuroendocrine tumor

Li-ming ZHU1,(), Hai-jun ZHONG1   

  1. 1. Department of Gastrointestinal oncology, Zhejiang cancer hospital, Hangzhou 310012, China
  • Received:2015-05-12 Published:2015-08-25
  • Corresponding author: Li-ming ZHU
  • About author:
    Corresponding author: ZHU Li-ming, Email:
引用本文:

朱利明, 钟海均. 胃肠胰神经内分泌肿瘤的临床诊治[J/OL]. 中华结直肠疾病电子杂志, 2015, 04(04): 385-391.

Li-ming ZHU, Hai-jun ZHONG. Clinical diagnosis and treatment of gastrointestinal pancreatic neuroendocrine tumor[J/OL]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2015, 04(04): 385-391.

胃肠胰神经内分泌肿瘤是起源于神经内分泌组织的一组异质性肿瘤,近年来生长抑素类似物已经应用于神经内分泌肿瘤的临床治疗,新药物如血管靶向治疗及mTOR通路阻滞药物等也为神经内分泌肿瘤的治疗带来新的曙光。

Gastroenteropancreatic neuroendocrine tumors(GEP-NETs)are a heterogeneous group of neoplasms arising from the diffuse neuroendocrine system.Somatostatin analogs, initially developed for control of hormonal syndromes, have recently been used to inhibit tumor growth.The advent of new therapies such as newer drugs, targeting angiogenesis and mammalian target of rapamycin(mTOR)pathway for PNETs and carcinoid tumors have introduced a paradigm shift in the management of this heterogeneous malignancy.

表1 胃肠胰神经内分泌肿瘤的分级标准表(WHO,2010)
[1]
Adsay V. Ki67 labeling index in neuroendocrine tumors of the gastrointestinal and pancreatobiliary tract: to count or not to count is not the question, but rather how to count.Am J Surg Pathol, 2012, 36(12): 1743-1746.
[2]
Yachida S, Vakiani E, White CM, et al.Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumors.Am J Surg Pathol, 2012, 36(2): 173-184.
[3]
Scarpa A, Mantovani W, Capelli P, et al.Pancreatic endocrine tumors: improved TNM staging and histopathological grading permit a clinically efficient prognostic stratification of patients.Mod Pathol, 2010, 23(6): 824-833.
[4]
Panzuto F, Boninsegna L, Fazio N, et al.Metastatic and locally advanced pancreatic endocrine carcinomas: analysis of factors associated with disease progression.J Clin Oncol, 2011, 10, 29(17): 2372-2377.
[5]
Dasari A, Yao JC.Gastrointestinal neuroendocrine tumors: slow but steady progress.Oncology, 2014, 28(9): 201362.
[6]
Gilbert JA.Lanreotide delays progression of neuroendocrine tumours.Lancet Oncol, 2014, 15(10): 418.
[7]
Engstrom PF, Lavin PT, Moertel CG, et al.Streptozocin plus fluorouracil versus doxorubicin therapy for metastatic carcinoid tumor.J Clin Oncol, 1984, 2(11): 1255-1259.
[8]
Dahan L, Bonnetain F, Rougier P, et al.Phase III trial of chemotherapy using 5-fluorouracil and streptozotocin compared with interferon alpha for advanced carcinoid tumors: FNCLCC-FFCD 9710.Endocr Relat Cancer, 2009, 16(4): 1351-1361.
[9]
Kulke MH, Bergsland EK, Ryan DP, et al.Phase II study of recombinant human endostatin in patients with advanced neuroendocrine tumors.J Clin Oncol, 2006, 24(22): 3555-3561.
[10]
Thearle MS, Freda PU, Bruce JN, et al.Temozolomide(Temodar®)and capecitabine(Xeloda®)treatment of an aggressive corticotroph pituitary tumor.Pituitary, 2011, 14(4): 418-424.
[11]
Hainsworth JD.Evolving understanding and management of poorly differentiated neuroendocrine tumors.Clin Adv Hematol Oncol, 2013, 11(12): 805-806.
[12]
Rinke A, Müller HH, Schade-Brittinger C, et al.PROMID Study Group.Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group.J Clin Oncol, 2009, 27(28): 4656-4663.
[13]
Caplin ME, Pavel M, Ĉwikla JB, et al.CLARINET Investigators.Lanreotide in metastatic enteropancreatic neuroendocrine tumors.N Engl J Med, 2014, 371(3): 224-233.
[14]
Pavel ME, Hainsworth JD, Baudin E, et al.RADIANT-2 Study Group.Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrinetumours associated withcarcinoid syndrome(RADIANT-2): a randomised, placebo-controlled, phase 3 study.Lancet, 2011, 378(9808): 2005-2012.
[15]
Yao JC, Shah MH, Ito T, et al.Everolimus for advanced pancreatic neuroendocrine tumors.RAD001 in Advanced Neuroendocrine Tumors, Third Trial(RADIANT-3)Study Group.N Engl J Med, 2011, 364(6): 514-523.
[16]
Raymond E, Dahan L, Raoul JL, et al.Sunitinib malate for the treatment of pancreatic neuroendocrine tumors.N Engl J Med, 2011, 364(6): 501-513.
[1] 张晓宇, 殷雨来, 张银旭. 阿帕替尼联合新辅助化疗对三阴性乳腺癌的疗效及预后分析[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 346-352.
[2] 梁晓宗, 江吉勇, 李曼丹, 林海彬, 王昌义. 阔筋膜游离股前外侧穿支皮瓣修复足踝组织缺损[J/OL]. 中华关节外科杂志(电子版), 2024, 18(05): 672-675.
[3] 张舒沁, 陈练. 产后宫腔内妊娠物残留的诊断和临床处理[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 493-497.
[4] 李友, 唐林峰, 杜伟伟, 刘海亮, 余新水, 沈佳宇, 巨积辉. 皮瓣联合掌长肌腱折叠单排三点式固定治疗指背侧创面伴锤状指畸形的临床效果观察[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(06): 485-490.
[5] 王强, 金光哲, 巨积辉, 王凯, 唐晓强, 吕文涛, 程贺云, 杨林, 王海龙. 超声辅助定位下游离臂内侧皮瓣在修复手指创面中的临床应用[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(05): 393-397.
[6] 刘敏, 唐恩溢, 刘喆, 葛苏蒙, 刘梅, 孙国文. 计算机导航技术在口腔颌面部微小异物取出手术中的应用[J/OL]. 中华口腔医学研究杂志(电子版), 2024, 18(06): 375-379.
[7] 孙莲, 马红萍, 吴文英. 局部进展期甲状腺癌患者外科处理[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 112-114.
[8] 赵毅, 李昶田, 唐文博, 白雪婷, 刘荣. 腹腔镜术中超声主胰管自动识别模型的临床应用[J/OL]. 中华腔镜外科杂志(电子版), 2024, 17(05): 290-294.
[9] 刘卓, 张宗明, 张翀, 刘立民, 赵月, 齐晖. 腹腔镜手术治疗高龄急性梗阻性化脓性胆管炎患者的安全性与术式选择[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 795-800.
[10] 陈宗杰, 胡添松. 肝外伤破裂患者治疗后胆漏发生影响因素分析[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 836-840.
[11] 王妍, 李征, 卓奇峰, 周陈杰, 吉顺荣, 徐晓武, 陈洁, 虞先濬. 微小无功能性胰腺神经内分泌瘤外科治疗进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 607-614.
[12] 魏妙艳, 徐近. 合并远处转移胰腺癌系统性治疗的梳理和展望[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 644-650.
[13] 雷永琪, 刘新阳, 杨黎渝, 铁学宏, 俞星新, 耿志达, 刘雨, 陈政良, 惠鹏, 梁英健. 肝脏血管周上皮样细胞肿瘤合并贫血一例并文献复习[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 710-718.
[14] 李宜璐, 曹永丽, 杨阳, 王思远, 张远耀, 杨维维, 王信琛, 陈俊, 魏东. 腹腔镜盆底修复联合PPH 术治疗直肠内脱垂的手术疗效观察[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(05): 394-401.
[15] 芦煜, 李振宇, 吴承东, 周仲伍. 肛周子宫内膜异位症一例报告[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(05): 431-434.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?