| [1] |
Chan TA.Nonsteroidal anti-inflammatory drugs，apoptosis，and colon-cancer chemoprevention.Lancet Oncol，2002,3(3):166-174.
|
| [2] |
Giardiello FM，Hamilton SR，Krush AJ，et al.Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis.N Engl J Med，1993,328(18):1313-1316.
|
| [3] |
Vane JR，Botting RM，Mechanism of action of antiinflammatory drugs.Int J Tissue React，1998,20(1):3–15.
|
| [4] |
Vane JR，Bakhle YS，Botting RM.Cyclooxygenases 1 and 2.Annu Rev Pharmacol Toxicol，1998,38:97–120.
|
| [5] |
Chakraborti AK，Garg SK，Kumar R，et al.Progress in COX-2 inhibitors: a journey so far.Curr Med Chem，2010,17(15):1563-1593.
|
| [6] |
Alberts DS，Hixson L，Ahnen D，et al.Do NSAIDs exert their colon cancer chemoprevention.activities through the inhibition of mucosal prostaglandinsynthetase? J Cell Biochem Suppl.1995;22:18-23.
|
| [7] |
Elder DJ，Halton DE，Hague A，et al.Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2(COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression.Clin Cancer Res，1997,3(10):1679-1683.
|
| [8] |
Hanif R，Pittas A，Feng Y，et al.Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway.Biochem Pharmacol，1996,52(2):237-245.
|
| [9] |
Kusuhara H，Matsuyuki H，Matsuura M，et al.Induction of apoptotic DNA fragmentation by nonsteroidal anti-inflammatory drugs in cultured rat gastric mucosal cells.Eur J Pharmacol，1998,360(2-3):273-280.
|
| [10] |
Carter CA，Ip MM，Ip C，A comparison of the effects of the prostaglandin synthesis inhibitors indomethacin and carprofen on 7，12-dimethylbenz[a]anthracene-induced mammary tumorigenesis in rats fed different amounts of essential fatty acid.Carcinogenesis，1989,10(8):1369–1374.
|
| [11] |
Erickson BA，Longo WE，Panesar N，et al.The effect of selective cyclooxygenase inhibitors on intestinal epithelial cell mitogenesis.J Surg Res，1999,81(1):101-107.
|
| [12] |
Tinsley HN，Gary BD，Thaiparambil J，et al.Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition.Cancer Prev Res(Phila)，2010,3(10):1303-1313.
|
| [13] |
Soh JW，Kazi JU，Li H，et al.Celecoxib-induced growth inhibition in SW480 colon cancer cells is associated with activation of protein kinase G．Mol Carcinog，2008,47(7):519-525.
|
| [14] |
Shiff SJ，Rigas B．The role of cyclooxygenase inhibition in the antineoplastic effects of nonsteroidal antiinflammatory drugs(NSAIDs)．J Exp Med，1999,190(4):445-450.
|
| [15] |
Eberhart CE，Coffey RJ，Radhika A，et al.Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas.Gastroenterology，1994,107(4):1183-1188.
|
| [16] |
Fujita T，Matsui M，Takaku K，et al.Size- and invasion-dependent increase in cyclooxygenase 2 levels in human colorectal carcinomas.Cancer Res，1998,58(21):4823-4826.
|
| [17] |
Sawaoka H，Kawano S，Tsuji S，et al.Effects of NSAIDs on proliferation of gastric cancer cells in vitro: possible implication of cyclooxygenase-2 in cancer development.J Clin Gastroenterol.1998;27 Suppl 1:S47-52.
|
| [18] |
Oshima M，Dinchuk JE，Kargman SL，et al.Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2(COX-2)．Cell，1996,87(5):803-809.
|
| [19] |
Arber N，Eagle CJ，Spicak J，et al.Celecoxib for the prevention of colorectal adenomatous polyps.N Engl J Med，2006,355(9):885-895.
|
| [20] |
Baron JA，Sandler RS，Bresalier RS，et al.A randomized trial of rofecoxib for the chemoprevention of colorectal adenomas.Gastroenterology，2006,131(6):1674-1682.
|
| [21] |
Kalgutkar AS，Rowlinson SW，Crews BC，et al.Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors.Bioorg Med Chem Lett，2002,12(4):521-524.
|
| [22] |
Beavo JA.Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms.Physiol Rev，1995,75(4):725-748.
|
| [23] |
Lincoln TM，Cornwell TL.Intracellular cyclic GMP receptor proteins.FASEB J，1993,7(2):328-338.
|
| [24] |
Shailubhai K，Yu HH，Karunanandaa K，et al.Uroguanylin treatment suppresses polyp formation in the Apc(Min/＋)mouse and induces apoptosis in human colon adenocarcinoma cells via cyclic GMP.Cancer Res，2000,60(18):5151-5157.
|
| [25] |
Soh JW，Mao Y，Kim MG，et al.Cyclic GMP mediates apoptosis induced by sulindac derivatives via activation of c-Jun NH2-terminal kinase 1.Clin Cancer Res，2000,6(10):4136-4141.
|
| [26] |
Silvola J，Kangasaho M，Tokola O，et al.Effects of nonsteroidal anti-inflammatory drugs on rat gastric mucosal phosphodiesterase activity.Agents Actions，1982,12(4):516-520.
|
| [27] |
Zhu B，Vemavarapu L，Thompson WJ，et al.Suppression of cyclic GMP-specific phosphodiesterase 5 promotes apoptosis and inhibits growth in HT29 cells.J Cell Biochem，2005,94(2):336-350.
|
| [28] |
Tinsley HN，Gary BD，Keeton AB，et al.Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin-mediated transcription in human breast tumor cells.Cancer Prev Res(Phila)，2011,4(8):1275-1284.
|
| [29] |
Piazza GA，Alberts DS，Hixson LJ，et al.Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels.Cancer Res，1997,57(14):2909-2915.
|
| [30] |
Thompson WJ，Piazza GA，Li H，et al.Exisulind induction of apoptosis involves guanosine 3'，5'-cyclic monophosphate phosphodiesterase inhibition，protein kinase G activation，and attenuated beta-catenin.Cancer Res，2000,60(13):3338-3342.
|
| [31] |
Toyokuni S，Okamoto K，Yodoi J，et al.Persistent oxidative stress in cancer.FEBS Lett，1995,358(1):1-3.
|
| [32] |
Frein D，Schildknecht S，Bachschmid M，et al.Redox regulation: a new challenge for pharmacology.Biochem Pharmacol，2005,70(6):811-823.
|
| [33] |
Rigas B，Kashfi K．Nitric-oxide-donating NSAIDs as agents for cancer prevention.Trends Mol Med，2004,10(7):324-330.
|
| [34] |
Williams JL，Kashfi K，Ouyang N，et al.NO-donating aspirin inhibits intestinal carcinogenesis in Min(APC(Min/＋))mice.Biochem Biophys Res Commun，2004,313(3):784-788.
|
| [35] |
Huang L，Zhu C，Sun Y，et al.Phospho-sulindac(OXT-922)inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect.Carcinogenesis，2010,31(11):1982-1990.
|
| [36] |
Altieri DC.Survivin and apoptosis control.Adv Cancer Res，2003,88:31-52.
|
| [37] |
Ambrosini G，Adida C，Altieri DC.A novel anti-apoptosis gene，survivin，expressed in cancer and lymphoma.Nat Med，1997,3(8):917-921.
|
| [38] |
Hoffman WH，Biade S，Zilfou JT，et al.Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.J Biol Chem，2002,277(5):3247-3257.
|
| [39] |
Pyrko P，Soriano N，Kardosh A，et al.Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog，dimethyl-celecoxib(DMC)，in tumor cells in vitro and in vivo.Mol Cancer，2006,5:19.
|
| [40] |
DuBois RN，Gupta R，Brockman J，et al.The nuclear eicosanoid receptor，PPARgamma，is aberrantly expressed in colonic cancers.Carcinogenesis，1998,19(1):49-53.
|
| [41] |
Lehmann JM，Lenhard JM，Oliver BB，et al.Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs.J Biol Chem，1997,272(6):3406-3410.
|
| [42] |
Ljungdahl S，Shoshan MC，Linder S．Inhibition of the growth of 12V-ras-transformed rat fibroblasts by acetylsalicylic acid correlates with inhibition of NF-kappa B．Anticancer Drugs，1997,8(1):62-66.
|
| [43] |
Rayet B，Gélinas C．Aberrant rel/nfkb genes and activity in human cancer.Oncogene，1999,18(49):6938-6947.
|
| [44] |
Schwenger P，Alpert D，Skolnik EY，et al.Activation of p38 mitogen-activated protein kinase by sodium salicylate leads to inhibition of tumor necrosis factor-induced IkappaB alpha phosphorylation and degradation.Mol Cell Biol，1998,18(1):78-84.
|
| [45] |
Baek SJ，Wilson LC，Lee CH，et al.Dual function of nonsteroidal anti-inflammatory drugs(NSAIDs): inhibition of cyclooxygenase and induction of NSAID-activated gene.J Pharmacol Exp Ther，2002,301(3):1126-1131.
|
| [46] |
Esquela-Kerscher A，Slack FJ.Oncomirs - microRNAs with a role in cancer.Nat Rev Cancer，2006,6(4):259-269.
|
| [47] |
Huang GL，Zhang XH，Guo GL，et al.Clinical significance of miR-21 expression in breast cancer: SYBR-Green I-based real-time RT-PCR study of invasive ductal carcinoma.Oncol Rep，2009,21(3):673-679.
|
| [48] |
Ma L，Reinhardt F，Pan E，et al.Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model.Nat Biotechnol，2010,28(4):341-347.
|
| [49] |
Zhu S，Wu H，Wu F，et al.MicroRNA-21 targets tumor suppressor genes in invasion and metastasis.Cell Res，2008,18(3):350-359.
|