Current research on the role of traditional Chinese medicine in modulating colorectal cancer stem cells to impede the progression of colorectal cancer

doi:10.3877/cma.j.issn.2095-3224.2025.04.009

Abstract

Abstract:

Colorectal cancer stem cells (CCSCs), as a subpopulation of tumorigenic cells with self-renewal and multi-directional differentiation capabilities in colorectal cancer, are the key factors leading to tumor recurrence, metastasis and drug resistance. Recent studies have shown that traditional Chinese medicine can exert anti-colorectal cancer effects through mechanisms such as regulating CCSCs-related signaling pathways, influencing the expression of stemness markers and inhibiting proliferation. This article systematically reviews the research progress of traditional Chinese medicine in regulating CCSCs, providing new strategies and theoretical basis for the treatment of colorectal cancer.

Key words: Colorectal cancer, Colorectal cancer stem cells, Traditional Chinese medicine

Ruoying Ke, Pei Wang, Bingwen Zhou, Zhimin Fan. Current research on the role of traditional Chinese medicine in modulating colorectal cancer stem cells to impede the progression of colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2025, 14(04): 364-369.

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