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Chinese Journal of Colorectal Diseases(Electronic Edition) ›› 2024, Vol. 13 ›› Issue (05): 411-416. doi: 10.3877/cma.j.issn.2095-3224.2024.05.009

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Research progress of functional constipation and anxiety and depression comorbidity

Ling Wang1, Wenbin Fan2, Jiachun Ni3, Zengjin Cai1,()   

  1. 1.Department of Proctology, Yongchuan Hospital of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 402160, China
    2.School of Nursing, Chongqing College of Traditional Chinese Medicine, Chongqing 402760, China
    3.Department of Coloproctology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, ShanghaiUniversity of Traditional Chinese Medicine, Shanghai 200437, China
  • Received:2024-07-14 Online:2024-10-25 Published:2024-11-14
  • Contact: Zengjin Cai

Abstract:

Functional constipation is a common clinical condition,with long-term sufferers frequently exhibiting tendencies toward anxiety and depression. Medication targeting anxiety and depression may exacerbate constipation,creating a vicious cycle of comorbidity. Therefore,effectively managing the coexistence of functional constipation and anxiety-depression is a crucial clinical challenge.Understanding the interaction mechanisms of such comorbidities and selecting appropriate psychosocial assessment questionnaires are key to treatment. This article explores the interaction mechanisms of functional constipation with anxiety and depression from the perspectives of the nervous system,abnormal brain-gut peptide secretion,gut microbiota,drug effects,and intestinal immune mechanisms. It also reviews related psychosocial assessment questionnaires,aiming to analyze the factors contributing to these conditions and to emphasize the importance of psychological assessment in treating constipation,providing a reference for the diagnosis and treatment of comorbid functional constipation and anxietydepression.

Key words: Functional Constipation, Anxiety, Depression, Comorbidity

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