Home    中文  
 
  • Search
  • lucene Search
  • Citation
  • Fig/Tab
  • Adv Search
Just Accepted  |  Current Issue  |  Archive  |  Featured Articles  |  Most Read  |  Most Download  |  Most Cited

Chinese Journal of Colorectal Diseases(Electronic Edition) ›› 2019, Vol. 08 ›› Issue (06): 553-559. doi: 10.3877/cma.j.issn.2095-3224.2019.06.003

Special Issue:

• Original Article • Previous Articles     Next Articles

Left and right sided colon cancer and programmed death-1 signaling pathway

Jinhong Xia1, Jin Gu1,()   

  1. 1. Department of Gastrointestinal Surgery III, Peking University Cancer Hospital & Institute, Beijing 100142, China
  • Received:2019-05-25 Online:2019-12-25 Published:2019-12-25
  • Contact: Jin Gu
  • About author:
    Corresponding author: Gu Jin, Email:

Abstract:

Objective

To investigate the effect of PD1/PDL1 pathway on the prognosis of left and right sided colon cancer and the role of PD1/PDL1 signaling pathway in the difference between left and right sided colon cancer.

Methods

The differential genes of left and right sided colon cancer were analyzed by data analysis. The expression and prognosis of PD1 (PDCD1), PDL1 (CD274), PDL2 (PDCD1L2) in left and right sided colon cancer were analyzed. The results of data analysis were verified by immunohistochemical method.

Results

TCGA data analysis showed that differentially expressed genes in left and right sided colon cancer were enriched in immune-related signaling pathways, including PD1 signaling pathway. The expression of PDCD1, CD274 and PDCD1L2 in right sided colon cancer was significantly higher than that in left sided colon cancer. Kaplan-Meier survival analysis showed that the overall survival rate (OS) of right sided colon cancer was worse than that of left sided colon cancer. In the high expression groups of PDCD1, CD274 and PDCD1L2, the overall survival rate of right sided colon cancer was worse than that of left sided colon cancer (P<0.05). Immunohistochemical results showed that the protein expression of PD1 and PDL1 in left and right colon cancers had the same results as TCGA data analysis. Kaplan-Meier survival analysis showed that the protein expression of PDL1 affects the prognosis of colon cancer, and the higher the overall expression The lower the survival rate.

Conclusion

The differential expression of PD1/PDL1 signaling pathway affects the prognosis of left and right colon cancer.

Key words: Colonic neoplasms, Prognosis, PD1/PDL1 pathway, Left and right sided colon cancer

京ICP 备07035254号-20
Copyright © Chinese Journal of Colorectal Diseases(Electronic Edition), All Rights Reserved.
Tel: 0086-010-87788026 E-mail: cjcd_editor@vip.163.com
Powered by Beijing Magtech Co. Ltd