We reported the experience of nursing care after tumor resection in a patient with presacral huge tumor and anemia. The key points of nursing after surgery: included the gauze compression measurement was used to pack hemostasis for severe presacral hemorrhage during tumor resection, then the patient was carefully monitored to prevent bleeding when the gauze was removed step by step; meanwhile, personal nursing plan was made to prevent various postoperative complications; additionally, psychological counseling was conducted and reinforced to alleviate fear response. In this paper, we summarized and shared some nursing experience in the process of diagnosis and treatment.