To explore the curative effects and influences of the serum cytokines level in patients with UC after the medication treatment combined salad oxazine with Chang weining.

Selecting forty-four patients with UC who came to Renmin Hospital of Wuhan University and accepted medication treatment. Twenty patients were only treated with salad oxazine and other twenty-four patients were treated with salad oxazine and Chang weining, then clinical efficacy was compared between the two groups. In addition, sixteen healthy people were chosen as normal control group, and the serum cytokine level of TGF-β and IGF-1 in two groups were measured before and after treatment with medications.

After treatments, the total efficiency of combination group (79.17%) was higher than that of single drug treatment group (50.00%), and the difference presented statistically significant (χ²=4.13, P=0.04). The levels of TGF-β1 and IGF-1 in the normal control group were (108.50±18.99) ng/L and (255.25±17.41) ng/L, respectively. After treatment, the combined drug treatment group [(92.46±16.76) ng/L, (221.25±11.56) ng/L] presented more significant changes than single drug treatment group [(79.45±14.44) ng/L, (181.80±12.12) ng/L]. Compared with the of serum cytokine level before treatment, both TGF-β and IGF-1 levels in two groups were increased, and the difference was statistically significant (single drug treatment group: t=-4.16, P=0.001; t=-14.22, P=0.000) (combined drug treatment group: t=-8.49, P=0.000; t=-26.7, P=0.000). Compared with the single drug treatment group, the level of cytokine in patients with combined drug treatment group was significantly higher, and the difference was statistically significant (t=2.02, P=0.01; t=2.02, P<0.001).

The total effective rate was increased by the combination of salad oxazine and Chang weining, and the serum cytokine level of TGF-β1 and IGF-1 of combination group were closer to the normal control group.