The role of vitamin D in the carcinogenesis, prevention and intervention of colorectal cancer

doi:10.3877/cma.j.issn.2095-3224.2018.06.004

Abstract

Abstract:

Colorectal cancer is a common malignant tumor in China, and its pathogenesis involves many aspects. Recently, both epidemiology and preclinical studies support that vitamin D deficiency might be one of the risk factors for colorectal cancer, and vitamin D supplement might reduce the incidence of colorectal cancer and even improve the efficacy of anti-tumor therapy. The ASCO meeting also has discussed the prospective studies. This article reviews the correlation between vitamin D and colorectal cancer occurrence and prevention, and discusses the role of vitamin D in the prevention and treatment of colorectal cancer.

Key words: Colorectal neoplasms, Vitamin D, Prevention, Intervention

Dongshao Chen, Xiaotian Zhang. The role of vitamin D in the carcinogenesis, prevention and intervention of colorectal cancer[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2018, 07(06): 518-522.

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References 35

[1]	Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015 [J]. CA Cancer J Clin, 2016, 66(2): 115-132.
[2]	Garland CF, Garland FC. Do sunlight and vitamin D reduce the likelihood of colon cancer? [J]. Int J Epidemiol, 1980, 9(3): 227-231.
[3]	Yin L, Ordonez-Mena JM, Chen T, et al. Circulating 25-hydroxyvitamin D serum concentration and total cancer incidence and mortality: a systematic review and meta-analysis [J]. Prev Med, 2013, 57(6): 753-764.
[4]	Grant WB. Ecological studies of the UVB-vitamin D-cancer hypothesis [J]. Anticancer Res, 2012, 32(1): 223-236.
[5]	Ma Y, Zhang P, Wang F, et al. Association between vitamin D and risk of colorectal cancer: a systematic review of prospective studies [J]. J Clin Oncol, 2011, 29(28): 3775-3782.
[6]	Holick MF. Vitamin D deficiency [J]. N Engl J Med, 2007, 357(3): 266-281.
[7]	Chiang KC, Chen TC. The anti-cancer actions of vitamin D [J]. Anticancer Agents Med Chem, 2013, 13(1): 126-139.
[8]	Campbell MJ, Adorini L. The vitamin D receptor as a therapeutic target [J]. Expert Opin Ther Targets, 2006, 10(5): 735-748.
[9]	Ogunkolade BW, Boucher BJ, Fairclough PD, et al. Expression of 25-hydroxyvitamin D-1-alpha-hydroxylase mRNA in individuals with colorectal cancer [J]. Lancet, 2002, 359(9320): 1831-1832.
[10]	Ditsch N, Toth B, Mayr D, et al. The association between vitamin D receptor expression and prolonged overall survival in breast cancer [J]. J Histochem Cytochem, 2012, 60(2): 121-129.
[11]	Lappe JM, Travers-Gustafson D, Davies KM, et al. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial [J]. Am J Clin Nutr, 2007, 85(6): 1586-1591.
[12]	Maalmi H, Ordonez-Mena JM, Schottker B, et al. Serum 25-hydroxyvitamin D levels and survival in colorectal and breast cancer patients: systematic review and meta-analysis of prospective cohort studies [J]. Eur J Cancer, 2014, 50(8): 1510-1521.
[13]	Li M, Chen P, Li J, et al. Review: the impacts of circulating 25-hydroxyvitamin D levels on cancer patient outcomes: a systematic review and meta-analysis [J]. J Clin Endocrinol Metab, 2014, 99(7): 2327-2336.
[14]	Fuchs MA, Yuan C, Sato K, et al. Predicted vitamin D status and colon cancer recurrence and mortality in CALGB 89803 (Alliance) [J]. Ann Oncol, 2017, 28(6): 1359-1367.
[15]	Wactawski-Wende J, Kotchen JM, Anderson GL, et al. Calcium plus vitamin D supplementation and the risk of colorectal cancer [J]. N Engl J Med, 2006, 354(7): 684-696.
[16]	Avenell A, MacLennan GS, Jenkinson DJ, et al. Long-term follow-up for mortality and cancer in a randomized placebo-controlled trial of vitamin D(3) and/or calcium (RECORD trial) [J]. J Clin Endocrinol Metab, 2012, 97(2): 614-622.
[17]	Trivedi DP, Doll R, Khaw KT. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial [J]. BMJ, 2003, 326(7387): 469.
[18]	Ng K, Scott JB, Drake BF, et al. Dose response to vitamin D supplementation in African Americans: results of a 4-arm, randomized, placebo-controlled trial [J]. Am J Clin Nutr, 2014, 99(3): 587-598.
[19]	Ross AC,Taylor CL,Yaktine AL, et al. Institute of Medicine Committee to Review Dietary Reference Intakes for Vitamin D, Calcium: The National Academies Collection: Reports funded by National Institutes of Health. In: Dietary Reference Intakes for Calcium and Vitamin D [M]. edn. Washington (DC): National Academies Press (US) National Academy of Sciences, 2011.
[20]	Chen G. Interpretation of the updates of NCCN 2017 version 1.0 guideline for colorectal cancer [J]. Chin J Gastrointest Surg, 2017, 20(1): 28-33.
[21]	Pradhan AD, Manson JE. Update on the Vitamin D and OmegA-3 trial (VITAL) [J]. J Steroid Biochem Mol Biol, 2016, 155(Pt B): 252-256.
[22]	Neale RE, Armstrong BK, Baxter C, et al. The D-Health Trial: A randomized trial of vitamin D for prevention of mortality and cancer [J]. Contemp Clin Trials, 2016, 48: 83-90.
[23]	Leslie A, Carey FA, Pratt NR, et al. The colorectal adenoma-carcinoma sequence [J]. Br J Surg, 2002, 89(7): 845-860.
[24]	Hummel DM, Thiem U, Hobaus J, et al. Prevention of preneoplastic lesions by dietary vitamin D in a mouse model of colorectal carcinogenesis [J]. J Steroid Biochem Mol Biol, 2013, 136: 284-288.
[25]	Fichera A, Little N, Dougherty U, et al. A vitamin D analogue inhibits colonic carcinogenesis in the AOM/DSS model [J]. J Surg Res, 2007, 142(2): 239-245.
[26]	Wei MY, Garland CF, Gorham ED, et al. Vitamin D and prevention of colorectal adenoma: a meta-analysis [J]. Cancer Epidemiol Biomarkers Prev, 2008, 17(11): 2958-2969.
[27]	Ahmad II, Trikudanathan G, Feinn R, et al. Low Serum Vitamin D: A Surrogate Marker for Advanced Colon Adenoma? [J]. J Clin Gastroenterol, 2016, 50(8): 644-648.
[28]	Alberts DS, Martinez ME, Roe DJ, et al. Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas. Phoenix Colon Cancer Prevention Physicians′ Network[J]. N Engl J Med, 2000, 342(16): 1156-1162.
[29]	Alberts DS, Martinez ME, Hess LM, et al. Phase III trial of ursodeoxycholic acid to prevent colorectal adenoma recurrence[J]. J Natl Cancer Inst, 2005, 97(11): 846-853.
[30]	Baron JA, Barry EL, Mott LA, et al. A trial of calcium and vitamin D for the prevention of colorectal adenomas [J]. N Engl J Med, 2015, 373(16): 1519-1530.
[31]	Barry EL, Peacock JL, Rees JR, et al. Vitamin D receptor genotype, vitamin D3 supplementation, and risk of colorectal adenomas: a randomized clinical trial [J]. JAMA Oncol, 2017, 3(5): 628-635.
[32]	DeSantis CE, Lin CC, Mariotto AB, et al. Cancer treatment and survivorship statistics, 2014 [J]. CA Cancer J Clin, 2014, 64(4): 252-271.
[33]	Mantell DJ, Owens PE, Bundred NJ, et al. 1 alpha, 25-dihydroxyvitamin D(3) inhibits angiogenesis in vitro and in vivo [J]. Circ Res, 2000, 87(3): 214-220.
[34]	Elez E, Argiles G, Tabernero J. First-line treatment of metastatic colorectal cancer: interpreting FIRE-3, PEAK, and CALGB/SWOG 80405 [J]. Curr Treat Options Oncol, 2015, 16(11): 52.
[35]	Ng K, Sargent DJ, Goldberg RM, et al. Vitamin D status in patients with stage IV colorectal cancer: findings from Intergroup trial N9741 [J]. J Clin Oncol, 2011, 29(12): 1599-1606.

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