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Chinese Journal of Colorectal Diseases(Electronic Edition) ›› 2016, Vol. 05 ›› Issue (06): 468-474. doi: 10.3877/cma.j.issn.2095-3224.2016.06.003

Special Issue:

• Forum for Expert • Previous Articles     Next Articles

Immune checkpoints blocking treatment of colorectal cancer

Shaozhong Wei1, Sheng Hu2,()   

  1. 1. Department of Gastrointestinal Surgery, Hubei Cancer Hospital, Hubei Cancer Hospital, Wuhan 430071, China
    2. Department of Medical Oncology, Hubei Cancer Hospital, Wuhan 430071, China
  • Received:2016-06-16 Online:2016-12-25 Published:2016-12-25
  • Contact: Sheng Hu
  • About author:
    Corresponding author: Hu Sheng, Email:

Abstract:

Colorectal cancer is one of the most common malignacies, and the overall prognosis is not satisfying. For patients with metastatic colorectal cancer, there is an urgent need to explore new efficient treatment methods. Immunotherapy, especially immune checkpoint inhibitors, are the current research focuses, which show excellent outcomes in melanoma and lung cancer. This review will outline the antitumor immunity and the new progress of a variety of immune checkpoint inhibitors in colorectal cancer.

Key words: Colorectal neoplasms, Therapy, Immune checkpoint, Immunotherapy

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