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Chinese Journal of Colorectal Diseases(Electronic Edition) ›› 2016, Vol. 05 ›› Issue (01): 47-51. doi: 10.3877/cma.j.issn.2095-3224.2016.01.09

Special Issue:

• Original Article • Previous Articles     Next Articles

The expression and clinical significance of caveolin-1 in colorectal cancer stroma

Zhi Zhao1, Fanghai Han2,()   

  1. 1. Department of Gastrointestinal Surgery, Guilin Medical College Affiliated Hospital, Guilin 541000, China
    2. Department of Gastrointestinal Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China
  • Received:2016-01-18 Online:2016-02-25 Published:2016-02-25
  • Contact: Fanghai Han
  • About author:
    Corresponding author:Han Fanghai, Email:

Abstract:

Objective

To investigate the clinicopathological signi?cance and prognostic value of Caveolin-1 (Cav-1) in colorectal cancer (CRC).

Methods

A total of 110 patients with CRC were included in this study. The correlation between Cav-1 expression and clinicopathologic features and survival was studied.

Results

Cav-1 expression was detected in tumor cytoplasm and cytomembrane. The expression of Cav-1 was closely associated with pathologic (p) TNM stage (P=0.037) and pN stage (P=0.011). Moreover, Kaplan-Meier analysis showed that high Cav-1 expression was associated with shorter overall survival and disease free survival (P<0.001 for both). Multivariate analysis revealed that the Cav-1 expression was an independent prognostic factor for overall survival (P<0.014).

Conclusion

The expression of Cav-1 in CRC was associated with poor prognosis and could be a prognostic factor for CRC patients.

Key words: Colorectal neoplasms, Prognosis, Caveolin-1

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