The influence of neoadjuvant chemotherapy of patients with colorectal cancer in immune function and tumor markers

doi:10.3877/cma.j.issn.2095-3224.2015.04.13

Abstract

Abstract:

Objective

To investigate the effects of neoadjuvant chemotherapy of stage II, III retal cancer on immune function and tumor markers.

Methods

To analyze 31 cases patients with rectal cancer of neoadjuvant chemotherapy, and monitor the tumor markers and immune function before and after chemotherapy.

Results

The comparison of CEA(P=0.049), CA242(P=0.048)levels between before and after chemotherapy in these 31 patients had significant difference; while CA199 has no significant difference(P=0.252). Only B cells immune function had significant difference(P=0.044), the rest of the total T cells, helper T cells, cytotoxic T cells, natural killer cells, CD4/CD8, or regulatory T cells showed no significant difference.

Conclusion

neoadjuvant chemotherapy can significantly reduce levels of CEA, CA242 patients in II, III stage rectal cancer; and had no effect on cellular immune function, only decreased B cell function.

Key words: Rectal cancer, Neoadjuvant chemotherapy, Tumor marker, Immune function

Yi-xun ZHANG, Yao-ping LI, Bo JIANG, Hai-yi LIU, Sheng-huai HOU, Yan-jun LU, Hai-bo WANG. The influence of neoadjuvant chemotherapy of patients with colorectal cancer in immune function and tumor markers[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2015, 04(04): 411-414.

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References 13

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?	0度	I度	II度	III度
消化道反应	5	18	7	1
骨髓抑制	13	17	1	0
肝功能	18	13	0	0
周围神经	3	26	2	0

?	0度	I度	II度	III度
消化道反应	5	18	7	1
骨髓抑制	13	17	1	0
肝功能	18	13	0	0
周围神经	3	26	2	0

组别	新辅助化疗前	新辅助化疗后	F	P
CEA	33.52±6.02	8.54±15.88	4.048	0.049
CA199	74.64±131.75	40.54±97.73	1.340	0.252
CA242	67.11±103.78	26.60±41.09	4.083	0.048
CD4＋CD8＋T细胞	69.23±11.39	72.34±9.22	1.399	0.242
CD4＋T细胞	36.28±7.5	38.14±10.03	0.682	0.412
CD8＋T细胞	28.53±7.85	31.21±8.62	1.640	0.205
CD4/CD8	1.36±0.43	1.40±0.85	0.077	0.782
NK细胞	20.42±10.45	18.56±9.88	0.517	0.475
调节性T细胞	6.37±2.25	5.81±1.41	1.402	0.241
B细胞	9.67±3.77	7.70±3.78	4.224	0.044

组别	新辅助化疗前	新辅助化疗后	F	P
CEA	33.52±6.02	8.54±15.88	4.048	0.049
CA199	74.64±131.75	40.54±97.73	1.340	0.252
CA242	67.11±103.78	26.60±41.09	4.083	0.048
CD4＋CD8＋T细胞	69.23±11.39	72.34±9.22	1.399	0.242
CD4＋T细胞	36.28±7.5	38.14±10.03	0.682	0.412
CD8＋T细胞	28.53±7.85	31.21±8.62	1.640	0.205
CD4/CD8	1.36±0.43	1.40±0.85	0.077	0.782
NK细胞	20.42±10.45	18.56±9.88	0.517	0.475
调节性T细胞	6.37±2.25	5.81±1.41	1.402	0.241
B细胞	9.67±3.77	7.70±3.78	4.224	0.044

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