Recurrent inflammatory granulation tissue hyperplasia at the small enterostomy is rare. Our center reported a case of a 67-year-old male who developed inflammatory granulation tissue hyperplasia at the small enterostomy 5 and 7 years after the small bowel obstruction surgery, respectively. We surgically removed the hyperplastic tissue, and postoperative pathology showed inflammatory granulation tissue hyperplasia without cancer cells. Although the probability of malignant transformation of inflammatory granulation tissue is extremely low, the risk of stoma cancer still needs to be considered. Therefore, this article summarized the treatment of the case to provide more evidence for clinical treatment.