The progress in research of molecular mechanism of circRNAs regulating colorectal cancer metastasis

doi:10.3877/cma.j.issn.2095-3224.2023.05.010

Abstract

Abstract:

Colorectal cancer is the third leading cause of cancer deaths worldwide, with its high recurrence and metastasis rates being the main reasons for poor prognosis. Therefore, the regulatory mechanism of colorectal cancer metastasis has become a hot topic of interest for domestic and international researchers. To date, however, the potential regulatory mechanisms of colorectal cancer metastasis remain incompletely understood. Many non-coding genes are involved in tumor invasion and spread, with circular RNAs (circRNAs) being important non-coding RNAs. CircRNAs may be involved in the colorectal carcinogenesis and metastasis. In this review, we systematically analyze the latest research on the role of circRNAs to regulate metastasis-related signaling pathways and the involvement of these circRNAs in colorectal cancer promotion and suppression. The regulatory network of circRNAs in the colorectal metastasis-related signaling pathway has been determined. Further analysis of the potential clinical applications of circRNAs as novel clinical diagnostic and prognostic biomarkers and therapeutic targets for colorectal cancer may provide new ideas and solutions for the prevention and treatment of colorectal cancer.

Key words: Colorectal neoplasms, Metastasis, CircRNA, Signal pathway

Boyang Fan, Ning Wang, Qian Zhang, Guiyu Wang. The progress in research of molecular mechanism of circRNAs regulating colorectal cancer metastasis[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2023, 12(05): 426-430.

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