To discuss the clinical application of three-port laparoscopic radical resection of colorectal cancer with natural orifice specimen extraction surgery (NOSES).

The clinical data of 8 patients with colorectal cancer who underwent three-port laparoscopic radical resection of colorectal cancer with natural orifice specimen extraction from Oct. 2021 to Dec. 2021 in the the First Affiliated Hospital of Sun Yat-sen University were retrospectively analyzed, including the operation duration, intraoperative bleeding, postoperative exhausting time, number of dissected lymph nodes, postoperative complications and hospital stay.

All operations of 8 patients were completed successfully, with average operative time (170.3±38.6) minutes, intraoperative bleeding (43.8±11.9) mL, postoperative exhausting time (42.0±24.9) hours, number of dissected lymph nodes (13.6±9.5) and average hospital stay (13.4±3.9) days. No postoperative complications were observed.

Three-port laparoscopic radical resection of colorectal cancer performed by 1 surgeon and 1 camera operator appears to be a feasible and safe surgical option for the treatment of patients with colorectal cancer, showing the same radical cure effect was achieved without increasing complications.