Collagen in colorectal cancer: current status and perspectives

doi:10.3877/cma.j.issn.2095-3224.2022.04.003

Abstract

Abstract:

Colorectal cancer (CRC) is the most common malignant tumor of digestive tract in the world. The incidence of CRC is increasing year by year. Collagen is the main component of extracellular matrix, which is crucial to the maintenance of tumor microenvironment (TME) and plays an important role in the occurrence, development and metastasis of CRC. Therefore, it is necessary to explore the role of collagen in CRC. This article makes a systematical review of the collagen-related researches in CRC in domestic and overseas.

Key words: Colorectal neoplasms, Collagen, Extracellular matrix

Jiahui Qiu, Chao Han, Chen Huang. Collagen in colorectal cancer: current status and perspectives[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2022, 11(04): 281-287.

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References 33

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胶原	组织沉积		胶原形状			胶原α链
胶原	间质	基底膜	纤维状纤维	网状纤维	其他	胶原α链
Ⅰ	√		√			α1（Ⅰ），α2（Ⅰ）
Ⅱ	√		√			α1（Ⅱ）
Ⅲ	√		√			α1（Ⅲ）
Ⅳ		√		√		α1（Ⅳ），α2（Ⅳ），α3（Ⅳ）， α4（Ⅳ），α5（Ⅳ），α6（Ⅳ）
Ⅴ	√		√			α1（Ⅴ），α2（Ⅴ），α3（Ⅴ），α4（Ⅴ）
Ⅵ		√	√			α1（Ⅵ），α2（Ⅵ），α3（Ⅵ）， α4（Ⅵ），α5（Ⅵ），α6（Ⅵ）
Ⅶ		√			√	α1（Ⅶ）
Ⅷ	√			√		α1（Ⅷ）
Ⅸ					√	α1（Ⅸ），α2（Ⅸ），α3（Ⅸ）
Ⅹ	√			√		α1（Ⅹ）
Ⅺ	√				√	α1（Ⅺ），α2（Ⅺ），α3（Ⅺ）
Ⅻ					√	α1（Ⅻ）
ⅩⅢ	√				√	α1（ⅩⅢ）
ⅩⅣ					√	α1（ⅩⅣ）
ⅩⅤ		√			√	α1（ⅩⅤ）
ⅩⅥ	√				√	α1（ⅩⅥ）
ⅩⅦ		√			√	α1（ⅩⅦ）
ⅩⅧ					√	α1（ⅩⅧ）
ⅩⅨ					√	α1（ⅩⅨ）
ⅩⅩ					√	α1（ⅩⅩ）
ⅩⅩⅠ					√	α1（ⅩⅩⅠ）
ⅩⅩⅡ					√	α1（ⅩⅩⅡ）
ⅩⅩⅢ		√			√	α1（ⅩⅩⅢ）
ⅩⅩⅣ			√			α1（ⅩⅩⅣ）
ⅩⅩⅤ					√	α1（ⅩⅩⅤ）
ⅩⅩⅥ					√	α1（ⅩⅩⅥ）
ⅩⅩⅦ			√			α1（ⅩⅩⅦ）
ⅩⅩⅧ					√	α1（ⅩⅩⅧ）

胶原	组织沉积		胶原形状			胶原α链
胶原	间质	基底膜	纤维状纤维	网状纤维	其他	胶原α链
Ⅰ	√		√			α1（Ⅰ），α2（Ⅰ）
Ⅱ	√		√			α1（Ⅱ）
Ⅲ	√		√			α1（Ⅲ）
Ⅳ		√		√		α1（Ⅳ），α2（Ⅳ），α3（Ⅳ）， α4（Ⅳ），α5（Ⅳ），α6（Ⅳ）
Ⅴ	√		√			α1（Ⅴ），α2（Ⅴ），α3（Ⅴ），α4（Ⅴ）
Ⅵ		√	√			α1（Ⅵ），α2（Ⅵ），α3（Ⅵ）， α4（Ⅵ），α5（Ⅵ），α6（Ⅵ）
Ⅶ		√			√	α1（Ⅶ）
Ⅷ	√			√		α1（Ⅷ）
Ⅸ					√	α1（Ⅸ），α2（Ⅸ），α3（Ⅸ）
Ⅹ	√			√		α1（Ⅹ）
Ⅺ	√				√	α1（Ⅺ），α2（Ⅺ），α3（Ⅺ）
Ⅻ					√	α1（Ⅻ）
ⅩⅢ	√				√	α1（ⅩⅢ）
ⅩⅣ					√	α1（ⅩⅣ）
ⅩⅤ		√			√	α1（ⅩⅤ）
ⅩⅥ	√				√	α1（ⅩⅥ）
ⅩⅦ		√			√	α1（ⅩⅦ）
ⅩⅧ					√	α1（ⅩⅧ）
ⅩⅨ					√	α1（ⅩⅨ）
ⅩⅩ					√	α1（ⅩⅩ）
ⅩⅩⅠ					√	α1（ⅩⅩⅠ）
ⅩⅩⅡ					√	α1（ⅩⅩⅡ）
ⅩⅩⅢ		√			√	α1（ⅩⅩⅢ）
ⅩⅩⅣ			√			α1（ⅩⅩⅣ）
ⅩⅩⅤ					√	α1（ⅩⅩⅤ）
ⅩⅩⅥ					√	α1（ⅩⅩⅥ）
ⅩⅩⅦ			√			α1（ⅩⅩⅦ）
ⅩⅩⅧ					√	α1（ⅩⅩⅧ）

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