Mixed constipation (MC) is a kind of functional constipation with clinical manifestations of both slow transit constipation (STC) and outlet obstructive constipation (OCC),which not only affects the quality of life of patients, but also causes serious damage to the physical and mental health of patients. Because the etiology of MC is complex, the pathogenesis is not clear, the current diagnostic ways and methods can not fully meet the clinical needs, and the treatment effect is poor, it is often called intractable constipation.This article reviews the literature on the etiology, pathogenesis, diagnosis and treatment of MC published in recent years, and provides references for finding new ways and methods for clinical diagnosis and treatment of MC.