Home    中文  
 
  • Search
  • lucene Search
  • Citation
  • Fig/Tab
  • Adv Search
Just Accepted  |  Current Issue  |  Archive  |  Featured Articles  |  Most Read  |  Most Download  |  Most Cited

Chinese Journal of Colorectal Diseases(Electronic Edition) ›› 2021, Vol. 10 ›› Issue (06): 631-637. doi: 10.3877/cma.j.issn.2095-3224.2021.06.010

• Original Article • Previous Articles     Next Articles

The relationship between tumor stromal maturity and prognosis of colorectal cancer: a Meta analysis

Wei Yang1, Jiejing Chen1, Wei Wu1, Maoan Liu1, Yong Dai1, Qing Ni1,()   

  1. 1. Department of General Surgery, the Affiliated Hospital of Yangzhou University, Yangzhou 225100, China
  • Received:2021-03-26 Online:2021-12-25 Published:2022-02-12
  • Contact: Qing Ni

Abstract:

Objective

To investigate the relationship between tumor stromal maturity and prognosis of colorectal cancer.

Methods

The literatures researching the relationship between tumor stromal maturity and prognosis of colorectal cancer were searched in the Wangfang, CNKI, CochraneLibrary, PubMed, SpringerLink, EBSCO, MEDLINE and other databases from database construction to January 2021, "tumor stroma maturity" "desmoplastic stroma reaction" "desmoplastic reaction" "stroma reaction" "degree of stroma reaction" "stroma classification" "stroma density" "colorectal cancer" "colon cancer" "rectal cancer" "prognosis" were selected as keywords, relevant clinical data were extracted according to the inclusion and exclusion criteria, and the quality of literatures were evaluated according to NOS form, the Meta-analysis was performed by RevMan5.4 and "metafor" R package.

Results

A total of 15 articles including 9 849 colorectal cancer patients in 19 cohorts were analysed in this Meta-analysis. These cohorts were composed by 4 339 patients with mature stroma (control group), 3 048 patients with intermediate stroma (intermediate group) and 2 456 patients with immature troma (immature group). The Meta-analysis results showed that there was significant difference between the immature group and control group in recurrence-free survival (HR=2.66, 95%CI: 2.30~3.08; P<0.00001), disease-free survival (HR=3.68, 95%CI: 2.33~5.81, P<0.00001) and overall survival (HR=1.70, 95%CI: 1.53~1.87; P<0.00001); there was also significant difference between the intermediate group and control group in RFS (HR=1.36, 95%CI: 1.17~1.59, P<0.0001) and DFS (HR=1.85, 95%CI: 1.53~2.24, P<0.0001).

Conclusion

The prognosis of colorectal cancer was closely related to the tumor stromal maturity.

Key words: Colorectal Neoplasms, Prognosis, Tumor stromal maturity, Meta-analysis

京ICP 备07035254号-20
Copyright © Chinese Journal of Colorectal Diseases(Electronic Edition), All Rights Reserved.
Tel: 0086-010-87788026 E-mail: cjcd_editor@vip.163.com
Powered by Beijing Magtech Co. Ltd