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Chinese Journal of Colorectal Diseases(Electronic Edition) ›› 2020, Vol. 09 ›› Issue (05): 433-439. doi: 10.3877/cma.j.issn.2095-3224.2020.05.001

Special Issue:

• Forum for Experts •     Next Articles

Progress in diagnosis and treatment of squamous cell anal carcinoma

Yao Lin1, Peng Zhang1, Kaixiong Tao1,()   

  1. 1. Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
  • Received:2019-09-28 Online:2020-10-25 Published:2020-10-25
  • Contact: Kaixiong Tao

Abstract:

Squamous cell anal carcinoma (SCAC) is a cancer with a low incidence, but the incidence has continued to increase in recent years. SCAC is a HPV-associated squamous cell carcinoma with risk factors including HPV, HIV infection, and high-risk life. The symptoms of SCAC are similar to those of rectal adenocarcinoma. The diagnosis is based on pathological biopsy, and 18F-FDG PET / CT scan is feasible to detect lymph node metastasis levels. In addition, the guidelines update the latest TNM staging and clinical staging of SCAC. The treatment of SCAC is mainly chemoradiotherapy, supplemented by surgical resection. In recent years, the chemoradiotherapy scheme has not only been the traditional 5-fluorouracil + mitomycin/platinum + RT scheme, drugs such as capecitabine, paclitaxel and other advanced radiotherapy technologies such as IMRT have been added to the therapeutic schedule. At the same time, related research on targeting and immunotherapy for SCAC treatment is also actively underway.

Key words: Anal canal, Squamous cell anal carcinoma, Epidemiology, Chemoradiotherapy, Targeted therapy, Progress

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