Ovarian metastases is the special metastasize form of colorectal cancer. Ovarian metastases have a poor prognosis in patients with colorectal cancer, and the combined therapy principle dominated by surgery should be followed. This case was successful case of multidisciplinary team (MDT) took individualized comprehensive treatment on patient with ovarian metastases from colorectal cancer. The patient was diagnosed with sigmoid colon carcinoma, and ovarian metastases was found in eleven months after sigmoid colon surgery. Through systemic chemotherapy and target therapy, timely and appropriate complete resection of hysterectomy and bilateral adnexectomy was achieved, and then to maintenance therapy. After disease progression, the patient was subjected to percutaneous biopsy and genetic testing, then tailored therapeutic regimen. The most recent follow-up revealed overall survival with fifty-one months. In this case report, we will report the treatment process and share some experience.