Delayed rectal anastomotic leakage associated with bevacizumab therapy: a case report

doi:10.3877/cma.j.issn.2095-3224.2019.01.015

Abstract

Abstract:

Bevacizumab is an anti vascular endothelial growth factor monoclonal antibody and commonly used in the clinical treatment of recurrent or metastatic colorectal cancer. Anastomotic complications are occasionally reported during the treatment. This report is a case of delayed type anastomotic leakage related to bevacizumab during the treatment of rectal cancer in the Gastrointestinal Surgery Center of West China Hospital of Sichuan University, and the literature was reviewed.

Key words: Rectal neoplasms, Bevacizumab, Delayed anastomotic leakage

Haoyan Wu, Chao Fang, Zongguang Zhou. Delayed rectal anastomotic leakage associated with bevacizumab therapy: a case report[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2019, 08(01): 74-75.

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References 10

[1]	Gordon MS, Cunningham D. Managing patients treated with bevacizumab combination therapy [J]. Oncology, 2005, 69(suppl 3): 25-33.
[2]	Adenis A, Vanseymortier L, Foissey D, et al. Bevacizumab and postponed suture leakages after surgery for ulcerative colitis and rectal cancer [J]. Gut, 2007, 56(5): 734.
[3]	Ley EJ, Vukasin P, Kaiser AM, et al. Delayed rectovaginal fistula: a potential complication of bevacizumab (Avastin) [J]. Dis Colon Rectum, 2007, 50(6): 930.
[4]	Ganapathi AM, Westmoreland T, Tyler D, et al. Bevacizumab-associated fistula formation in postoperative colorectal cancer patients [J]. J Am Coll Surg, 2012, 214(4): 582-588.
[5]	Bege T, Lelong B, Viret F, et al. Bevacizumab-related surgical site complication despite primary tumor resection in colorectal cancer patients [J]. Ann Surg Oncol, 2009, 16(4): 856-860.
[6]	Lim M, Akhtar S, Sasapu K, et al. Clinical and subclinical leaks after low colorectal anastomosis: A clinical and radiologic study [J]. Dis Colon Rectum, 2006,49(10): 1611-1619.
[7]	Tibbs MK. Wound healing following radiation therapy: A review [J]. Radiother Oncol,1997, 42(2): 99-106.
[8]	Bege T, Lelong B, Viret F, et al. Bevacizumab-related surgical site complication despite primary tumor resection in colorectal cancer patients [J]. Ann Surg Oncol, 2009, 16(4): 856-860.
[9]	Badgwell BD, Camp ER, Feig B, et al. Management of bevacizumab-associated bowel perforation: A case series and review of the literature [J]. Ann Oncol, 2007, 19(3): 577-582.
[10]	Scappaticci FA, Fehrenbacher L, Cartwright T, et al. Surgical wound healing complications in metastatic colorectal cancer patients treated with bevacizumab [J]. J Surg Oncol, 2005,91(3): 173-180.

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