With the development of minimally invasive surgery, laparoscopic surgery has become the gold standard for colon cancer. There is involved high risk in laparoscopic radical right colectomy for its complex anatomical structure, especially for the cases with obesity and mesentery edema. Based on our previous clinical practice of laparoscopic surgery for colon cancer and further understanding of colon mesentery, the author forwards a caudal-to-cranial approach for laparoscopic radical right colectomy to make the procedure easier. Cut the peritoneum along the line between the right mesocolon and retroperitoneum, enter the Toldt′s space to dissect the posterior of SMV/SMA and their branches, and then finished the D3 dissection from caudal to cranial on both sides of the mesentery along the SMV. In the end, cut the lateral ligament to mobilize the posterior space of ascending colon. This approach is called caudal-to-cranial approach. Here, the paper to conclude its techniques and advantages.