Based on the trend of high incidence of colorectal cancer in our country and the challenges of many cases of locally advanced and recurrent colorectal cancer, to define the concept of complex colorectal cancer is helpful to explore the standardized and individualized multidisciplinary treatment strategy. Optimization of clinical diagnosis and treatment strategy for the complex colorectal cancer is the key to improve the curative effect of the disease. This paper aims to put forward some general principles for the discussion in fellows, hoping to trigger thinking of the overall grasp for the colorectal cancer, which includes the principle of balance, the principle of dynamic and multi-dimensional evaluation system, goal oriented, concept of overall chronic diseases management, mechanism of MDT, how to view the guidelines and so on. Only if enhancing the comprehensive understanding of the disease and controlling the whole process of the illness, can we fulfill the standardization, reasonable, appropriate and individualized treatment of tumor in the contemporary medical model. The concept of the treatment for complex colorectal cancer is full of the integration of philosophy and medical thought, both methodology and dialectics, which is not only the pursuit of survival, but also permeated with humanistic care.