切换至 "中华医学电子期刊资源库"

中华结直肠疾病电子杂志 ›› 2019, Vol. 08 ›› Issue (05) : 501 -504. doi: 10.3877/cma.j.issn.2095-3224.2019.05.012

所属专题: 文献

综述

循环肿瘤细胞检测方式及临床应用
方超1, 周总光1,()   
  1. 1. 610041 四川大学华西医院胃肠外科中心
  • 收稿日期:2018-05-18 出版日期:2019-10-25
  • 通信作者: 周总光

The detection methods and clinical applications of circulation tumor cells

Chao Fang1, Zongguang Zhou1,()   

  1. 1. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdun 610041, China
  • Received:2018-05-18 Published:2019-10-25
  • Corresponding author: Zongguang Zhou
  • About author:
    Corresponding author: Zhou Zongguang, Email:
引用本文:

方超, 周总光. 循环肿瘤细胞检测方式及临床应用[J]. 中华结直肠疾病电子杂志, 2019, 08(05): 501-504.

Chao Fang, Zongguang Zhou. The detection methods and clinical applications of circulation tumor cells[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2019, 08(05): 501-504.

循环肿瘤细胞(CTC)指从实体肿瘤原发病灶或转移病灶脱落进入循环系统的肿瘤细胞亚群,其在肿瘤疾病进展、转移、复发中发挥着重要作用。CTC的有效检测及纯化对其临床应用、肿瘤疾病进展、转移及复发的机制研究尤为重要,并为肿瘤的个体化治疗提供可能。

Circulating tumor cells (CTC) are tumor cellular subpopulations in the peripheral circulation derived from primary or metastases, and play an important role in tumor progression, metastasis and recurrence. The effective detection and purification of CTC is especially important for the clinical application and the further analysis of mechanism of tumor progression, metastasis and recurrence. Also, it may provide the individualized treatment for tumor patients in the future.

[1]
Vicki Plaks, Charlotte D, Koopman, et al. Circulating Tumor Cells [J]. Science, 2013, 341(6151): 1186-1188.
[2]
Pantel K, Alix-Panabieres C, Riethdorf S. Cancer micrometastases [J]. Nat Rev Clin Oncol, 2009, 6(6): 339-351.
[3]
Chaffer CL, Weinberg RA. A perspective on cancer cell metastasis [J]. Science, 2011, 331(6024): 1559-1564.
[4]
Baccelli I, Schneeweiss A, Riethdorf S, et al. Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay [J]. Nat Biotechnol, 2013, 31(6): 539-544.
[5]
Berezovskaya O, Schimmer AD, Glinskii AB, et al. Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells [J]. Cancer Res, 2005, 65(6): 2378-2386.
[6]
Hou JM, Greystoke A, Lancashire L, et al. Evaluation of circulating tumor cells and serological cell death biomarkers in small cell lung cancer patients undergoing chemotherapy [J]. Am J Pathol, 2009, 175(2): 808-816.
[7]
Gazzaniga P, Gianni W, Raimondi C, et al. Circulating tumor cells in high-risk nonmetastatic colorectal cancer [J]. Tumour Biol, 2013, 34(5): 2507-2509.
[8]
Kling J. Beyond counting tumor cells [J]. Nat Biotechnol, 2012, 30(7): 578-580.
[9]
Yu M, Stott S, Toner M, et al. Circulating tumor cells: approaches to isolation and characterization [J]. J Cell Biol, 2011, 192(3): 373-382.
[10]
Paterlini-Brechot P, Benali NL. Circulating tumor cells (CTC) detection: clinical impact and future directions [J]. Cancer Lett, 2007, 253(2): 180-204.
[11]
Gormally E, Caboux E, Vineis P, et al. Circulating free DNA in plasma or serum as biomarker of carcinogenesis: practical aspects and biological significance [J]. Mutat Res, 2007, 635(2-3): 105-117.
[12]
Schwarzenbach H, Chun FK, Lange I, et al. Detection of tumor-specific DNA in blood and bone marrow plasma from patients with prostate cancer [J]. Int J Cancer, 2007, 120(7): 1465-1471.
[13]
Schwarzenbach H, Alix-Panabières C, Müller I, et al. Cell-free tumor DNA in blood plasma as a marker for circulating tumor cells in prostate cancer [J]. Clin Cancer Res, 2009, 15(3): 1032-1038.
[14]
Pantel K, Brakenhoff RH, Brandt B. Detection, clinical relevance and specific biological properties of disseminating tumor cells [J]. Nat Rev Cancer, 2008, 8(5): 329-340.
[15]
Mohamed H, Murray M, Turner JN, et al. Isolation of tumor cells using size and deformation [J]. J Chromatogr A, 2009, 1216(47): 8289-8295.
[16]
Vona G, Sabile A, Louha M, et al. Isolation by size of epithelial tumor cells: a new method for the immunomorphological and molecular characterization of circulating tumor cells [J]. Am J Pathol, 2000, 156(1): 57-63.
[17]
Marrinucci D, Bethel K, Bruce RH, et al. Case study of the morphologic variation of circulating tumor cells [J]. Hum Pathol, 2007, 38(3): 514-519.
[18]
Zheng S, Lin H, Liu JQ, et al. Membrane microfilter device for selective capture, electrolysis and genomic analysis of human circulating tumor cells [J]. J Chromatogr A, 2007, 1162(2): 154-161.
[19]
Mejean A, Vona G, Nalpas B, et al. Detection of circulating prostate derived cells in patients with prostate adenocarcinoma is an independent risk factor for tumor recurrence [J]. J Urol, 2000, 163(6): 2022-2029.
[20]
Riethdorf S, Fritsche H, Müller V, et al. Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the Cell Search system [J]. Clin Cancer Res, 2007, 13(3): 920-928.
[21]
Attard G, Swennenhuis JF, Olmos D, et al. Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer [J]. Cancer Res, 2009, 69(7): 2912-2918.
[22]
Nagrath S, Sequist LV, Maheswaran S, et al. Isolation of rare circulating tumour cells in cancer patients by microchip technology [J]. Nature, 2007, 450(7173): 1235-1239.
[23]
Shannon L. Stott, Chia-Hsien Hsu, Dina I. Tsukrov, et al. Isolation of circulating tumor cells using a microvortex-generating herringbone-chip [J]. Proc Natl Acad Sci U.S.A, 2010,107(43): 18392-18397.
[24]
Orfao A, Rodríguez C, Adansa JC, et al. Evaluation of multiparameter flow cytometry for the detection of breast cancer tumor cells in blood samples [J]. Am J Clin Pathol, 2005, 123(1): 66-74.
[25]
Rhim AD, Mirek ET, Aiello NM, et al. EMT and dissemination precede pancreatic tumor formation [J]. Cell, 2012, 148(1-2): 349-361.
[26]
Yu M, Bardia A, Wittner BS, et al. Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition [J]. Science, 2013, 339(6119): 580-584.
[27]
Haraguchi N, Ohkuma M, Sakashita H, et al. CD133CD44population efficiently enriches colon cancer initiating cells [J]. Ann Surg Oncol, 2008, 15(10): 2927-2933.
[28]
Pang R, Law WL, Chu AC, et al. A subpopulation of CD26 cancer stem cells with metastatic capacity in human colorectal cancer [J]. Cell Stem Cell, 2010, 6(6): 603-615.
[29]
Ahmed MA, Al-Attar A, Kim J, et al. CD24 shows early upregulation and nuclear expression but is not a prognostic marker in colorectal cancer [J]. J Clin Pathol, 2009, 62(12): 1117-1122.
[30]
Lugli A, Iezzi G, Hostettler I, et al. Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer [J]. Br J Cancer, 2010, 103(3): 382-390.
[31]
Pachmann K, Camara O, Kavallaris A, et al. Quantification of the response of circulating epithelial cells to neodadjuvant treatment for breast cancer: a new tool for therapy monitoring [J]. Breast Cancer Res, 2005a, 7(6): R975-R979.
[32]
He W, Wang H, Hartmann LC, et al. In vivo quantitation of rare circulating tumor cells by multiphoton intravital flow cytometry [J]. Proc Natl Acad Sci USA, 2007,104(28): 11760-11765.
[33]
Maheswaran S, Sequist LV, Nagrath S, et al. Detection of mutations in EGFR in circulating lung-cancer cells [J]. N Engl J Med, 2008, 359(4): 366-377.
[34]
Botteri E, Sandri MT, Bagnardi V, et al. Modeling the relationship between circulating tumour cells number and prognosis of metastatic breast cancer [J]. Breast Cancer Res Treat, 2010, 122(1): 211-217.
[35]
de Bono JS, Scher HI, Montgomery RB, et al. Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer [J]. Clin Cancer Res, 2008, 14(19): 6302-6309.
[36]
Cohen SJ, Alpaugh RK, Gross S, et al. Isolation and characterization of circulating tumor cells in patients with metastatic colorectal cancer [J]. Clin Colorectal Cancer, 2006, 6(2): 125-132.
[37]
Ignatiadis M, Xenidis N, Perraki M, et al. Different prognostic value of cytokeratin-19 mRNA positive circulating tumor cells according to estrogen receptor and HER2 status in early-stage breast cancer [J]. J Clin Oncol, 2007, 25(33): 5194-5202.
[38]
Cohen SJ, Alpaugh RK, Gross S, et al. Isolation and characterization of circulating tumor cells from localized and metastatic prostate cancer patients [J]. Sci Transl Med, 2010a, 2(25): 25ra23.
[39]
Pierga JY, Bidard FC, Mathiot C, et al. Circulating tumor cell detection predicts early metastatic relapse after neoadjuvant chemotherapy in large operable and locally advanced breast cancer in a phase II randomized trial [J]. Clin Cancer Res, 2008, 14(21): 7004-7010.
[1] 黄泽, 张梓榆, 杨青宇, 赖声清, 李海燕. 乳腺腔镜手术临床应用现状及训练路径[J]. 中华乳腺病杂志(电子版), 2023, 17(02): 122-125.
[2] 张华, 孙宇, 乡世健, 李樱媚, 王小群. 循环肿瘤细胞预测晚期胃肠癌患者化疗药物敏感性的研究[J]. 中华普通外科学文献(电子版), 2023, 17(06): 422-425.
[3] 冯雪园, 韩萌萌, 马宁. 循环肿瘤细胞的检测及其在乳腺癌中的应用[J]. 中华普通外科学文献(电子版), 2023, 17(03): 231-236.
[4] 叶啟发. 生物人工肝血液净化材料研究现状[J]. 中华移植杂志(电子版), 2023, 17(02): 0-.
[5] 杜静怡, 徐兴祥. 循环肿瘤细胞在非小细胞肺癌中的研究进展[J]. 中华肺部疾病杂志(电子版), 2023, 16(04): 596-600.
[6] 褚依然, 岳麓. 液体活检技术在肺癌中的应用进展[J]. 中华肺部疾病杂志(电子版), 2023, 16(01): 125-127.
[7] 国宇, 周全红, 孟凡祺. 双源CT联合循环肿瘤细胞对独立性肺结节的预测意义[J]. 中华肺部疾病杂志(电子版), 2023, 16(01): 61-63.
[8] 王庭丰, 陈爱民, 陈欣, 周芸娜, 颜红莲, 夏晓阳. CTC水平与非小细胞肺癌临床及病理特征的关系[J]. 中华肺部疾病杂志(电子版), 2022, 15(05): 676-678.
[9] 袁久莉, 刘丹, 李林藜, 刘晋宇. 毛囊间充质干细胞的基础研究及临床应用[J]. 中华细胞与干细胞杂志(电子版), 2023, 13(03): 189-192.
[10] 乔梁, 杨向群. 脂肪干细胞在心肌损伤修复中的研究进展[J]. 中华细胞与干细胞杂志(电子版), 2022, 12(04): 230-236.
[11] 毛宁, 朱勇. 胆汁酸性腹泻的发生机制与诊断[J]. 中华结直肠疾病电子杂志, 2022, 11(05): 425-428.
[12] 佘重阳, 卢弘. Janus激酶抑制剂在幼年特发性关节炎相关葡萄膜炎治疗中的研究进展[J]. 中华眼科医学杂志(电子版), 2023, 13(02): 104-108.
[13] 马嘉蹊, 米倩倩, 周义仁, 王丹. 阿达木单抗在眼科临床应用的新进展[J]. 中华眼科医学杂志(电子版), 2022, 12(06): 377-381.
[14] 吴绍伟. 迷走神经电刺激术治疗神经系统疾病的应用进展[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(03): 180-184.
[15] 霍俊艳, 傅瑜. 卵圆孔未闭检测方法临床应用研究进展[J]. 中华脑血管病杂志(电子版), 2022, 16(05): 310-313.
阅读次数
全文


摘要